Micotherapy Shitake

Immune system modulator

Food supplement containing organically grown Shiitake (Lentinula edodes) (IT BIO 006) – Made in Europe.

Health benefits:

Shiitake has traditionally been used in the East Medicine to boost the immune response, improve gut and oral microbiota, protectig mucous membranes from oral disease and infections.

Properties:

Shiitake is rich in bioactive molecules, micro and macronutrients, minerals, amino acids, vitamins, enzymes, fibres and secondary metabolites. The amino acids include significant amounts of glutamic acid, also called “brain food”, which stimulates the production of neurotransmitters and the transport of potassium in the brain. It contains high levels of polysaccharides (beta-glucans), including Lentinan, a branched beta-glucan (β 1-3 β 1-6), which has shown significant immunomodulating properties. A particularly effective substance contained in Shiitake is eritadenine, considered the most important bioactive component responsible for lowering cholesterol levels.

Ingredients:

  • Organically grown Shiitake (Lentinula edodes) sporophorum (IT BIO 006)

Directions:
3 capsules per day, preferably away from meals.

Pack:
pack containing 90 capsules
vegetable cellulose capsules

Notes:
Gluten free
ICEA Organic certified product
No GMO
Made in Europe

AVERAGE CONTENT OF CHARACTERISING INGREDIENTS PER DAILY DOSE (4 CAPSULES)
Shiitake sporophorum 1500 mg

BIBLIOGRAPHY:

  1. Wasser SP, et al. Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current per- spectives. Int J Med Mushrooms 1999;1:31-62
  2. Chibata I, et al. Lentinacin: a new hypocholesterolemic substance in Lentinus edodes. Experientia 1969;25:1237-8
  3. Sugiyama K, et al. Eritadenine-induced alteration of hepatic phospholipid metabolism in relation to its hypocholesterolemic action in rats. J Nutr Biochem 1995; 6:80-7
  4. Steinberg D, et al. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320:915-24
  5. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4
  6. Flynn, V.T. 1991. Is the shiitake mushroom an aphrodisiac and a cause of longevity. From: Science and Cultivation of Edible Fungi (Maher, ed.). Rotterdam: Balkema
  7. Fruehauf JP, 1982. The effect of lentinan on production of interleukin-1 by human monocytes. Immunopharmacology 5(1), 65-7
  8. Aiko WATANABE et al. Protection against D-Galactosamine-Induced Acute Liver Injury by Oral Administration of Extracts from Lentinus edodes Mycelia. Biol. Pharm. Bull. 29(8) 1651—1654 (2006)
  9. Ki Nam Yoon, et al. Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats. Mycobiology 39(2) : 96-102 (2011)
  10. Shoji Odani et al. The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes. Eur. J. Biochem. 262, 915±923 (1999) q FEBS 1999
  11. M. Fukushima. Cholesterol-Lowering Effects of Maitake (Grifola frondosa) Fiber, Shiitake (Lentinus edodes) Fiber, and Enokitake (Flammulina velutipes) Fiber in Rats. Exp Biol Med Vol. 226(8):758–765, 2001
  12. Sullivan R, Smith JE, Rowan NJ. Medicinal Mushrooms and Cancer Therapy: translating a traditional practice into Western medicine. Perspectives in Biology and Medicine. 2006; 49(2): 159-170
  13. Yeung KS, Gubili J. Shiitake Mushroom ( Lentinula edodes ). J Soc Integr Oncol . 2008;6(3):134-135
  14. Miyaji CK, Poersch A, Ribeiro LR, Eira AF, Cólus IM. Shiitake ( Lentinula edodes (Berkeley) Pegler) extracts as a modulator of micronuclei induced in HEp-2 cells. Toxicol In Vitro . 2006;20(8):1555-1559
  15. Israilides C, Kletsas D, Arapoglou D, et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes . Phytomedicine . 2008;15(6-7):512-519
  16. Yang P, Liang M, Zhang Y, Shen B. Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC. Adv Ther . 2008;25(8):787-794
  17. Maekawa S, Saku M, Kinugasa T, et al. 1990;17:137-140
  18. Suzuki M, Higuchi S, Taki Y, Taki S, Miwa K, Hamuro J. Induction of endogenous lymphokine-activated killer activity by combined administration of lentinan and interleukin 2. Int J Immunopharmacol . 1990;12(6):613-623
  19. gawa K, Watanabe T, Katsube T, et al. Study on intratumor admionistration of lentinan – primary changes in cancerous tissues [in Japanese]. Gan To Kagaku Ryoho . 1994;21(13):2101-2104
  20. 9Yin Y, Fu W, Fu M, He G, Traore L. The immune effects of edible fungus polysaccharides compounds in mice. Asia Pac J Clin Nutr . 2007;16(suppl 1):258-260
  21. Yu S, Weaver V, Martin K, Cantorna MT. The effects of whole mushrooms during inflammation. BMC Immunol . 2009;10:12
  22. Lee JY, Kim JY, Lee YG, Rhee MH, Hong EK, Cho JY. Molecular mechanism of macrophage activation by Exopolysaccharides from liquid culture of Lentinus edodes . J Microbiol Biotechnol . 2008;18(2):355-364
  23. Péter G, Károly V, Imre B, János F, Kaneko Y. Effects of lentian on cytotoxic functions of human lymphocytes. Immunopharmacol Immunotoxical . 1988;10(2):157-163
  24. Takeshita K, Saito N, Sato Y, et al. Diversity of complement activation of lentinan, an antitumor polysaccharide, in gastric cancer patients [in Japanese]. Nippon Geka Gakkai Zasshi . 1991;92(1):5-11
  25. Tani M, Tanimura H, Yamaue H, et al. Augmentation of lymphokine-activated killer cell activity by lentinan. Anticancer Res . 1993;13(5C):1773-1776
  26. Tani M, Tanimura H Yamaue H, et al. In vitro generation of activated natural killer cell sand cytotoxic macrophages with lentinan. Eur J Clin Pharmacol . 1992;42(6):623-627
  27. Arinaga S, Karimine N, Takamuku K, et al. Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. Int J Immunopharm . 1992;14(4):535-539
  28. Arinaga S, Karimine N, Nanbara S, et al. Enhanced production of interleukin 1 and tumor necrosis factor by peripheral monocytes after lentinan administration in patients with gastric carcinoma. Int J Immunopharm . 1992;14(1):43-47
  29. Zhou LD, Zhang QH, Zhang Y, Liu J, Cao YM. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses. Int Immunopharmacol . 2009;9(4):455-462
  30. Kaneko Y, Chihara G. Potentiation of host resistance against microbial infections by lentinan and its related polysaccharides. Adv Exp Med Biol . 1992;319:201-215
  31. Guo Z, Hu Y, Wang D, et al. Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine. Vaccine . 2009;27(5):660-665
  32. Hearst R, Nelson D, McCollum G, et al. An examination of antibacterial and antifungal properties of constituents of Shiitake ( Lentinula edodes ) and oyster ( Pleurotus ostreatus ) mushrooms. Complement Ther Clin Pract . 2009;15(1):5-7
  33. Tochikura T, Nakashima H, Kaneko Y, Kobayashi N, Yamamoto N. Suppression of human immunodeficiency virus replication by 3′-azido-3′-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan. Jpn J Cancer Res . 1987;78(6):583-589
  34. Yoshida O, Nakashima H, Yoshida T, et al. Sulfation of the immunodulating polysacchraride lentinan: a novel strategy for antivirals to human immunodeficiency virus (HIV). Biochem Pharmacol . 1988;37(15);2887-2891
  35. Gordon M, Bihari B, Goolsby E, et al. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial. J Med . 1998;29:305-330
  36. Ngai PHK, Ng TB. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci . 2003;73(26):3363-3374
  37. Chibata I, Okumura K, Takeyama S, et al, Lentinacin: a new hypocholesterolemic substance in Lentinus edodes . Experientia . 1969;25:1237-1238
  38. Rivera A, Benavides OL, Rios-Motta J. (22E)-Ergosta-6,22-diene-3beta,5alpha,8alpha-triol: a new polyhydroxysterol isolated from Lentinus edodes (Shiitake). Nat Prod Res . 2009;23(3):293-300
  39. Chihara G. Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Dev Biol Stand . 1992;77:191-197
  40. Aalto-Korte K, Susitaival P, Kaminska R, Mäkinen-Kiljunen S. Occupational protein contact dermatitis from shiitake mushroom and demonstration of shiitake-specific immunoglobulin E. Contact Dermatitis . 2005;53(4):211-213
  41. Suzuki K, Tanaka H, Sugawara H, et al. Chronic hypersensitivity pneumonitis induced by Shiitake mushroom spores associated with lung cancer. Intern Med . 2001;40(11):1132-1135
  42. Mak RK, Wakelin SH. Shiitake dermatitis: the first case reported from a European country. Br J Dermatol . 2006;154(4):800-801
  43. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J of Allergy Clin Immunol . 1998;101(5):613-620
  44. Ciric L et al. In Vitro Assessment of Shiitake Mushroom (Lentinula edodes) Extract for Its Antigingivitis Activity. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 507908, 7 pages
  45. Signoretto C et al. Testing a Low Molecular Mass Fraction of a Mushroom (Lentinus edodes) Extract Formulated as an Oral Rinse in a Cohort of Volunteers. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 857987, 7 pages
  46. Zaura E et al. The Effects of Fractions from Shiitake Mushroom on Composition and Cariogenicity of Dental Plaque Microcosms in an In Vitro Caries Model. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 135034, 10 pages
  47. Lingstrom P et al. The Anticaries Effect of a Food Extract (Shiitake) in a Short-Term Clinical Study. Journal of Biomedicine and BiotechnologyVolume 2012 (2012), Article ID 217164, 10 pages
  48. Venturini M et al. Antimicrobial Activity of Extracts of Edible Wild and Cultivated Mushrooms against Foodborne Bacterial Strains. Journal of Food Protection®, Number 8, August 2008, pp. 1544-1741 , pp. 1701-1706(6)
  49. Bisen PS et al Lentinus edodes: A Macrofungus with Pharmacological Activities Current Medicinal Chemistry, 2010, 17, 2419-2430 2419