Promotes the drainage of body fluids.

• Polyporus umbellatus sporophorum, from organic farming (IT BIO 006)
• anti-caking agents: calcium carbonate, silicon dioxide
• Capsule in vegetable cellulose

3 capsules per day, preferably before meals

Pack of 90 capsules

• Gluten free
• No OGM
• Organic ingredients – Made in Europe
• Listed in the supplement register: code 84612
• Paraf Code: 970430361

1. Chang, H.M. & P.P. But, 1986. Pharmacology and Applications of Chinese Materia Medica. Vol. 1. Singapore, World Scientific
2. Yuan D, Mori J, Komatsu KI, Makino T, Kano Y. An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium. Biol Pharm Bull. 2004 27(6):867-70
3. Satish H, Raman D, Shivananda BG, Kshama D, Rajesh MS, Deepak M, Shivananda TN. Antiurolithiatic herbal drugs – a review. Biomed. 2006 1(2):95-119
4. JJ Li, YY Tu, JZ Tong, and PT Wang Inhibitory activity of Dianthus superbus L. and 11 kinds of diuretic Traditional Chinese medicines for urogenital Chlamydia trachomatis in vitro Zhongguo Zhong Yao Za Zhi, Oct 2000; 25(10): 628-30
5. Inaoka Y, Shakuya A, Fukazawa H, Ishida H, Nukaya H, Tsuji K, Kuroda H, Okada M, Fukushima M, Kosuge T.Studies on active substances in herbs used for hair treatment. I. Effects of herb extracts on hair growth and isolation of an active substance from Polyporus umbellatus F. Chem Pharm Bull (Tokyo). 1994 42(3):530-3
6. Ishida H, Inaoka Y, Shibatani J, Fukushima M, Tsuji K. Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries. Biol Pharm Bull. 1999 22(11):1189-92
7. Yang D, Li S, Wang H, Li X, Liu S, Han W, Hao J, Zhang H. [Prevention of postoperative recurrence of bladder cancer: a clinical study] Zhonghua Wai Ke Za Zhi. 1999 37(8):464-5. Chinese
8. Yang DA. [Inhibitory effect of Chinese herb medicine Zhuling on urinary bladder cancer. An experimental and clinical study] Zhonghua Wai Ke Za Zhi. 1991 29(6):393-5, 399. Chinese
9. Zhang Guo-Wei et al. Efficacy of Zhuling polyporus polysaccharide with BCG to inhibit bladder carcinoma. Carbohydrate Polymers. Volume 118, 15 March 2015, Pages 30–35
10. Yang Y et al. Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. Journal of Ethnopharmacology Volume 169, 1 July 2015, Pages 49–59
11. Bandara AR et al. Polyporus umbellatus, an Edible-Medicinal Cultivated Mushroom with Multiple Developed Health-Care Products as Food, Medicine and Cosmetics: A Review . Cryptogamie, Mycologie 36(1):3-42. 2015?
12. Chen D.Q., An J.M., Feng Y.L., Tian T., Qin X.Y. & Zhao Y.Y., 2013 — Cloud-point extraction combined with liquid chromatography for the determination of ergosterol, a natural product with diuretic activity, in rat plasma, urine, and faeces. Journal of analytical methods in chemistry. Available at: http://dx.doi.org/10.1155/2013/479056
13. Bi Y., Miao Y., Han Y., Xu J. & Wang Q., 2013 — Biological and physicochemical properties of two polysaccharides from the mycelia of Grifola umbellata. Carbohydrate Polymers 95: 740–745
14. Zhao YY et al. A Pharmaco-Metabonomic Study on Chronic Kidney Disease and Therapeutic Effect of Ergone by UPLC-QTOF/HDMS. PLOS ONE | DOI:10.1371/journal.pone.0115467 December 23, 2014
15. Zhao YY. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: A review. Journal of Ethnopharmacology 149 (2013) 35–48
16. Zhao YY. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: A serum metabonomic study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx?i-FIT algorithm. Clinica Chimica Acta 413 (2012) 1438–1445
17. Zhao YY et al. Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. J Pharm Pharmacol. 2011 Dec;63(12):1581-6
18. Zhang G et al. Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats. Journal of Ethnopharmacology 128 (2010) 433–437
19. Zhao YY et al. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochimica et Biophysica Acta 1810 (2011) 384–390
20. Zhao YY et al. Cytotoxic Steroids from Polyporus umbellatus. Planta Med 2010; 76: 1755–1758
21. Zhao YY et al. Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus. Journal of Ethnopharmacology 126 (2009) 184–187
22. Lee WY et al. Cytotoxic Activity of Ergosta-4,6,8(14),22- tetraen-3-one from the Sclerotia of Polyporus umbellatus. Bull Korean Chem Soc. 2005 Vol 26 n.9
23. Sekiya N et al. Inhibitory Effects of Triterpenes Isolated from Chuling (Polyporus umbellatus FRIES) on Free Radical-Induced Lysis of Red Blood Cells. Biol. Pharm. Bull. 28(5) 817—821 (2005)